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Title:: Estimation of HIV type 1 incidence with BED-CEIA among high-risk populations in Henan, 2009

作者:: 崔为国¹; 刘佳¹; 聂玉刚¹; 李洁¹; 田随安¹; 孙国清¹; 孙定勇¹; 肖瑶²; 朱谦¹; 王哲¹; 1. 河南省疾病预防控制中心性病艾滋病防治研究所，郑州450016；2.中国疾病预防控制中心性艾中心参比实验室

Author(s):: CUI Wei-guo¹; LIU Jia¹; NIE Yu-gang¹; LI Jie¹; TIAN Sui-an¹; SUN Guo-qing¹; SUN Ding-yong¹; XIAO Yao²; ZHU Qian¹; WANG Zhe¹; 1. Institute for Prevention and Control of STD and AIDS, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan 450016 , China; 2. HIV Reference Laboratory, National Center for AIDS/STD Control and Prevention, Beijing 102206, China

摘要:: 目的：了解河南省三类哨点（男男性行为者、吸毒和性病门诊男性就诊者）和单阳配偶人群2009年的HIV新近感染情况。方法：收集2009年河南省男男性行为者、吸毒和性病门诊男性就诊者及单阳配偶人群各534、1 757、4 767及11 468例，通过酶联免疫和蛋白印迹实验检测出HIV-1感染的样品，再应用BED HIV-1发病捕获酶免疫测定法(BED HIV-1 capture enzyme immunoassay，简称BED-CEIA)检测出其中的新近感染样品，进而估算新近感染率。结果：河南省2009年男男性行为者、吸毒和性病门诊男性就诊者哨点的新发感染率分别为4.50%、0.46%和0.13%。单阳配偶人群的新近感染率为0.39%。结论：河南省2009年男男性行为人群新发感染率较高，同时不同地区单阳配偶人群的新近感染率有较大差别。

Abstract:: Objective To estimate human immunodeficiency virus type 1 (HIV-1) incidence with BED-CEIA among men who have sex with man (MSM), drug users, male STD clinic attenders and people who have HIV infected spouses/sexual partners. Methods We tested 534, 1757 and 4 767 and 11 468 individuals of MSM, drug users, male STD clinic attenders and having HIV infected spouses/sexual partners for HIV infection in 2009. HIV-1 antibody was tested by ELISA and Western Blot. Anti-HIV positive samples were confirmed with BED-capture enzyme immunoassay (BED-CEIA). HIV-1 incidence rates were estimated with the testing results. Results HIV-1 incidence rates were 4.50%, 0.46% and 0.13% for MSM, drug users and male STD clinic attenders respectively in 2009. HIV-1 incidence was 0.36% for people who have HIV infected spouses/sexual partners. Conclusions MSM population had a high incidence rate of HIV-1 infection and people who have HIV infected spouses/sex partners had varied incidence rates among different areas.