|本期目录/Table of Contents|

 母婴麻疹IgG抗体水平Meta分析及相互关系的研究(/HTML)

《中国病毒病杂志》[ISSN:2095-0136/CN:11-5969/R]

期数:
2011年02期
页码:
123-127
栏目:
论著
出版日期:
2011-04-01

文章信息/Info

Title:
 Meta-analysis on the relationship of measles IgG antibody levels between mothers and infants
作者:
 丰达星张珍英徐瑾郭万申
 河南省疾病预防控制中心
Author(s):
 FENG Da-xing ZHANG Zhen-ying XU Jin GUO Wan-shen
 Henan Provincial Center for Disease Control and Prevention,Zhengzhou,Henan450016,China
关键词:
 麻疹抗体Meta分析
Keywords:
Measles Antibody Meta-analysis
分类号:
R183.3
DOI:
-
文献标识码:
A
摘要:
 目的 研究母亲与其所生子女之间麻疹IgG抗体阳性率,抗体几何平均滴度(GMT)的相互关系。方法 收集有关开展母婴麻疹抗体配对研究,并报告抗体阳性率、抗体GMT的文献,运用RevMan软件对母婴抗体阳性率、抗体GMT进行Meta分析,并进行相关性研究。结果 共选取8篇文献进行Meta分析,在所有纳入研究的8篇文献中,母亲抗体阳性率为86.3%,平均抗体滴度为1?612.94,婴儿抗体阳性率为83.5%,平均抗体滴度为1?549.27。母婴抗体阳性率的RR值为1.08,95%可信区间(CI)为0.97~1.20,即母婴抗体阳性率差异无统计学意义,母婴抗体GMT值的SMD值为0.02,95% CI- 0.33~0.38),差异无统计学意义,相关性分析显示,两抗体阳性率相关Pearson系数r=0.87,P<0.05,差异有统计学意义,新生儿抗体阳性率随母体的增高而增高,两抗体滴度相关Spearman系数r=0.16,P<0.05,差异有统计学意义,新生儿抗体滴度随母体的增高而增高。结论 母婴麻疹抗体阳性率有一定关系,在我国进入麻疹消除阶段以后,除了维持高的免疫接种率以外,通过对育龄期妇女的麻疹疫苗的免疫,间接提高其出生婴儿的麻疹抗体水平,避免其在达到免疫月龄前感染麻疹病毒,也是一个积极有效的方法。
Abstract:
 

Objective To determine the relationship of measles IgG antibody levels between mothers and infants. Methods 8 published papers were found for the study. The levels of measles antibody were determined by positive rate and geometry mean titer (GMT). A meta-analysis was carried out to investigate the correlation of measles antibody between mothers and infants by RevMan4.2.2 software. Results The data sets of 8 papers had homogenized results and were all included in the analysis. The positive rates of measles antibody were 86.3% and 83.5% for mothers and infants (odds ratio: 1.29, 95% CI: 1.02~1.64), respectively. The GMTs of measles antibody were 1:612.94 and 1:549.27 respectively for mothers and infants. The standardized mean difference (SMD) of GMT was 0.02 (95% CI: -0.33~0.38).Meta-analysis showed the correlation of measles antibody levels between mothers and infants (r=0.86,P<0.05). Conclusions Maternal measles IgG antibody had association with the antibody of infants younger than 8 months. It is important to immune reproductive age women with measles vaccine for the protection of their infants in future.

参考文献/References

 

备注/Memo

备注/Memo:
更新日期/Last Update: 2011-04-15