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Title:: Meta-analysis on the relationship of measles IgG antibody levels between mothers and infants

Author(s):: FENG Da-xing; ZHANG Zhen-ying; XU Jin; GUO Wan-shen; Henan Provincial Center for Disease Control and Prevention，Zhengzhou，Henan450016，China

摘要:: 目的研究母亲与其所生子女之间麻疹IgG抗体阳性率，抗体几何平均滴度（GMT）的相互关系。方法收集有关开展母婴麻疹抗体配对研究，并报告抗体阳性率、抗体GMT的文献，运用RevMan软件对母婴抗体阳性率、抗体GMT进行Meta分析，并进行相关性研究。结果共选取8篇文献进行Meta分析，在所有纳入研究的8篇文献中，母亲抗体阳性率为86.3%，平均抗体滴度为1?612.94，婴儿抗体阳性率为83.5%，平均抗体滴度为1?549.27。母婴抗体阳性率的RR值为1.08，95%可信区间（CI）为0.97～1.20，即母婴抗体阳性率差异无统计学意义，母婴抗体GMT值的SMD值为0.02，95% CI（- 0.33～0.38），差异无统计学意义，相关性分析显示，两抗体阳性率相关Pearson系数r=0.87，P＜0.05，差异有统计学意义，新生儿抗体阳性率随母体的增高而增高，两抗体滴度相关Spearman系数r=0.16，P＜0.05，差异有统计学意义，新生儿抗体滴度随母体的增高而增高。结论母婴麻疹抗体阳性率有一定关系，在我国进入麻疹消除阶段以后，除了维持高的免疫接种率以外，通过对育龄期妇女的麻疹疫苗的免疫，间接提高其出生婴儿的麻疹抗体水平，避免其在达到免疫月龄前感染麻疹病毒，也是一个积极有效的方法。

Abstract:: Objective To determine the relationship of measles IgG antibody levels between mothers and infants. Methods 8 published papers were found for the study. The levels of measles antibody were determined by positive rate and geometry mean titer (GMT). A meta-analysis was carried out to investigate the correlation of measles antibody between mothers and infants by RevMan4.2.2 software. Results The data sets of 8 papers had homogenized results and were all included in the analysis. The positive rates of measles antibody were 86.3% and 83.5% for mothers and infants (odds ratio: 1.29, 95% CI: 1.02～1.64), respectively. The GMTs of measles antibody were 1:612.94 and 1:549.27 respectively for mothers and infants. The standardized mean difference (SMD) of GMT was 0.02 (95% CI: -0.33～0.38）.Meta-analysis showed the correlation of measles antibody levels between mothers and infants (r=0.86，P＜0.05). Conclusions Maternal measles IgG antibody had association with the antibody of infants younger than 8 months. It is important to immune reproductive age women with measles vaccine for the protection of their infants in future.